Repeated mild injury causes cumulative damage to hippocampal cells
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چکیده
منابع مشابه
Repeated mild injury causes cumulative damage to hippocampal cells.
An interesting hypothesis in the study of neurotrauma is that repeated traumatic brain injury may result in cumulative damage to cells of the brain. However, post-injury sequelae are difficult to address at the cellular level in vivo. Therefore, it is necessary to complement these studies with experiments conducted in vitro. In this report, the effects of single and repeated traumatic injury in...
متن کاملRepeated Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) represents a significant public healthcare concern, accounting for the majority of all head injuries. While symptoms are generally transient, some patients go on to experience long-term cognitive impairments and additional mild impacts can result in exacerbated and persisting negative outcomes. To date, studies using a range of experimental models have reporte...
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AIM To advance our understanding of regional and temporal cellular responses to repeated mild traumatic brain injury (rmTBI), we used a mouse model of rmTBI that incorporated acceleration, deceleration and rotational forces. MATERIALS & METHODS A modified weight-drop method was used to compare two inter-injury intervals, rmTBI-short (five hits delivered over 3 days) and rmTBI-long (five hits ...
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BACKGROUND The computerization of the workforce in the last two decades has led to increases in the incidence of repetitive strain injury (RSI). U.S. Workers Compensation claims made by persons disabled in the upper extremities in 1989 were estimated to be $563 million. METHOD Through an investigation of factors that increase the likelihood of contracting an RSI in various industries, the aut...
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We examined the brain damage following repeated hypotensive episodes in the rat. Severe hypotension was induced by withdrawal of arterial blood. The MABP was maintained at about 25 mm Hg with isoelectric EEG and the shed blood was retransfused. After 1 week of recovery, histopathological changes were examined. No brain damage was observed after 1 min of isoelectric EEG. Mild neuronal damage to ...
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ژورنال
عنوان ژورنال: Brain
سال: 2002
ISSN: 1460-2156
DOI: 10.1093/brain/awf271